A human gut ecosystem protects against C. difficile disease by targeting TcdA
نویسندگان
چکیده
منابع مشابه
A DNA vaccine targeting TcdA and TcdB induces protective immunity against Clostridium difficile
BACKGROUND Clostridium difficile-associated disease (CDAD) constitutes a great majority of hospital diarrhea cases in industrialized countries and is induced by two types of large toxin molecules: toxin A (TcdA) and toxin B (TcdB). Development of immunotherapeutic approaches, either active or passive, has seen a resurgence in recent years. Studies have described vaccine plasmids that express ei...
متن کاملAntibody against TcdB, but not TcdA, prevents development of gastrointestinal and systemic Clostridium difficile disease.
BACKGROUND A dramatic increase in morbidity and mortality from Clostridium difficile infection (CDI) due to the recent emergence of virulent, antibiotic-resistant strains has led to a search for alternatives to antibiotics, including vaccines and immune-based therapy that target the 2 key toxins-TcdA and TcdB. METHODS We investigated the efficacy of specific human monoclonal antibodies (HuMab...
متن کاملRunning Head: Gut Inflammation and C. difficile
4 Charles Darkoh, Bradley P. Turnwald, Hoonmo L. Koo, Kevin W. Garey, Zhi5 Dong Jiang, Samuel L. Aitken, Herbert L. DuPont 6 The University of Texas School of Public Health-Center For Infectious Diseases, 7 Houston, Texas 77030, USA, The University of Texas Medical School, Houston, Texas 8 77030, USA, St. Luke’s Episcopal Hospital, Internal Medicine, Houston, Texas 77030, 9 USA, Baylor College ...
متن کاملGut microbiota protects against gastrointestinal tumorigenesis caused by epithelial injury.
Inflammation is a critical player in the development of both colitis-associated and sporadic colon cancers. Several studies suggest that the microbiota contribute to inflammation and tumorigenesis; however, studies to understand the role of the microbiota in colon tumor development in germ-free (GF) mice are limited. We therefore studied the effects of the microbiota on the development of infla...
متن کاملProtective Effect of Carvacrol against Gut Dysbiosis and Clostridium difficile Associated Disease in a Mouse Model
This study investigated the effect of carvacrol (CR), a phytophenolic compound on antibiotic-associated gut dysbiosis and C. difficile infection in a mouse model. Five to six-week-old C57BL/6 mice were randomly divided into seven treatment groups (challenge and control) of eight mice each. Mice were fed with irradiated feed supplemented with CR (0, 0.05, and 0.1%); the challenge groups were mad...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Gastroenterology
سال: 2016
ISSN: 0944-1174,1435-5922
DOI: 10.1007/s00535-016-1232-y